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Tag Archives: Warfarin

Drug Interactions to Warfarin


Drugs may interact with warfarin sodium through pharmacodynamic or pharmacokinetic mechanisms. Pharmacodynamic mechanisms for drug interactions with warfarin sodium are synergism (impaired hemostasis, reduced clotting factor synthesis), competitive antagonism (vitamin K), and alteration of the physiologic control loop for vitamin K metabolism (hereditary resistance). Pharmacokinetic mechanisms for drug interactions with warfarin sodium are mainly enzyme […]

Nine agents in one Rx. and twenty drug interactions found (Not finished)


This afternoon I met a perscription that consist of nine different agents, which have twenty drug interactions. Many of them are cardiovascular drugs. They areĀ  Beta-Blockers, Electrolytes, Statins, ARBs, Inotropic Agents, Thiazide, Calcium Channel Blockers, and Benzodiazepines. I list them and their dosage below. Alprazolam 0.4 mg po Qd Metoprolol 12.5 mg po Bid Potassium […]

A serious drug interaction was found last week in 416 Hospital


Last week, before the “May 1st Labor Festival” an old man came to outpatient pharmacy to take his medications. Someone doctor (Neurology Clinics of 416 Hospital) prescribled the drug – Fluoxetine Capsule – to the old man. When I was dispensing the fluoxetine capsule (Dosage and frequency : 20mg po Qd) to the lovely old […]