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Tag Archives: VWF

[Hemostasis] General – Diagnostic Approach to the Bleeding Disorders


Clinical Presentations and Clinical Distinction Between Platelet- or Vessel-Induced Bleeding and Coagulation-Induced Bleeding Certain signs and symptoms are virtually diagnostic of disordered hemostasis. They can be divided arbitrarily into two groups: those seen more often in disorders of blood coagulation and those most commonly noted in disorders of the vessels and platelets. The latter group […]

Hemostasis Mechanism – Platelet Structure and Function


Platelet Granules and Organelles Platelets possess secretory granules and mechanisms for cargo release to amplify responses to stimuli and influence the surrounding environment. Platelet granule structures include 𝛼- and dense granules, lysosomes, and peroxisomes. 𝛼-Granules and the dense bodies are the main secretory granules that release cargo (e.g., fibrinogen and adenosine diphosphate [ADP]) upon platelet […]

[Physiology][Hematology] Coagulation Factors, Anticoagulation Factors, and Pathways of Hemostasis and Thrombosis


The role of surfaces in coagulation and coagulation inhibition and fibrinolysis Functionally, the relationship between clotting and surface is striking. For a process that is typically termed humoral, most of the coagulation reactions take place on biologic surfaces. The presence of a phospholipid surface increases the rate of activation of prothrombin by several orders of magnitude. […]

Thrombotic Thrombocytopenic Purpura and Its Management


Thrombotic thrombocytopenic purpura (TTP) is the common name for adults with microangiopathic hemolytic anemia, thrombocytopenia, with or without neurologic or renal abnormalities, and without another etiology for thrombotic microangiopathy (TMA). In 10 years before, we believed that the classic clinical features of TTP which was called “classic pentad” were thrombocytopenia, microangiopathic hemolytic anemia, neurologic abnormalities, […]