Skip to content

Tag Archives: transporters

Pharmacokinetics – Distribution Series

11-Nov-17

As a result of either direct systemic administration or absorption from an extravascular route, drug reaches the systemic circulation, where it very rapidly distributes throughout the entire volume of plasma water and is delivered to tissues around the body. Two aspects of drug distribution need to be considered: how radidly, and to what extent, the […]

[Endocrinology] The Agonist-Receptor Interaction and Pharmacodynamics of Thyroid Hormone

14-Oct-16

Thyroid Hormone Receptors and Cellular Events Thyroid hormone receptors are expressed in virtually all tissues and affect multiple cellular events. The cellular actions of thyroid hormones are mediated by multiple thyroid hormone receptor isoforms derived from 2 distinct genes (alpha and beta) encoding thyroid hormone receptors. The functional significance of the different isoforms has not yet […]