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Tag Archives: Prostaglandins

Control of the Circulating RAAS


The activity of the circulating RAAS is governed by the amount of renin secreted by the granular cells of the jg (juxtaglomerular) apparatus. There are 3 major controllers of renin secretion. PS: Look at the RAAS, plasma angiotensinogen is synthesized in the liver and plasma angiotensinogen levels are normally high therefore do not limit the production […]

Arteriolar Tone and Its Regulation (Local Mechanisms)


I.Arteriolar Tone A.Basal tone B.ANS C.Adrenal Glands D.Local 1.Metabolic substances 2.Endothelial cells secretion 3.Other local chemical influences 4.Transmural pressure (myogenic response) II.Venous Tone A.Basal tone (little) B.ANS C.Adrenal glands D.Internal pressure (recall deltaV/deltaP = C) E.External compression (muscle pump) Because the body's needs are continually changing, the cardiovascular system must continually make adjustments in the diameter […]

Inflammation Mediators


The mediators of inflammation are the substances that initiate and regulate inflammatory reactions. The most important inflammation mediators include vasoactive amines, lipid products (prostaglandins and leukotrienes), cytokines (including chemokines), and products of complement activation. These mediators induce various components of the inflammatory response typically by distinct mechanisms, which is why inhibiting each has been therapeutically beneficial. However, there is also some […]