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Tag Archives: plasma protein binding

Pharmacokinetics – Distribution Series


As a result of either direct systemic administration or absorption from an extravascular route, drug reaches the systemic circulation, where it very rapidly distributes throughout the entire volume of plasma water and is delivered to tissues around the body. Two aspects of drug distribution need to be considered: how radidly, and to what extent, the […]

Factors That Alter Clearance


Body Surface Area (BSA) Most literature values for clearance are expressed as volume/kg/time or as volume/70 kg/time. There is some evidence, however, that drug clearance is best adjusted on the basis of BSA rather than weight. The patient’s BSA can be obtained from a nomogram, estimated from below: BSA in m2 = [(Patient’s Weight in […]