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Tag Archives: Passive Diffusion

Pharmacokinetics – Distribution Series II – Rate of Drug Distribution

13-Nov-17

Figure 4.1 shows the plasma concentration and the typical tissue concentration profile after the administration of a drug by intravenous injection. It can be seen that during the distribution phase, the tissue concentration increases as the drug distributes to the tissue. Eventually, a type of equilibrium is reached, and following this, in the postdistribution phase, […]

Drug Absorption in the Gastrointestinal Tract

07-Apr-16

Rate-Limiting Steps in Drug Absorption Disintegration of the drug product and subsequent release of the drug (rate-limiting step) Dissolution of the drug in an aqueous environment (rate-limiting step) Absorption across the cell membranes into the systemic circulation (rate-limiting step) Physiochemical Factors that Affect Drug Absorption Drug disintegration (rate-limiting step) Drug dissolution (rate-limiting step) Drug across the cell […]

Biopharmaceutics – Drug Absorption – Part One – Passage of Drugs Across Cell Membranes

25-Feb-16

Key Ways For Drugs Across Cell Membranes Passive Diffusion Facilitated Diffusion Active Transport Passive Diffusion Passive diffusion is the major absorption process for most drugs. Theoretically, a lipophilic drug may pass through the cell or go around it. If the drug has a low molecular weight and is lipophilic, the lipid cell membrane is not […]