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Tag Archives: Maintenance Dose

The TDM of Vancomycin

16-Aug-16

Question #1. B.C., a 65-year old, 45-kg man with a serum creatinine concentration of 2.2 mg/dL, is being treated for a presumed hospital-acquired, MRSA infection. Design a dosing regimen that will produce peak concentration less than 40 to 50 mg/L and through concentrations of 5 to 15 mg/L. Target Plasma Concentration Clearance and Volume of […]

Extended-Release Drug Products

08-Jul-16

Most conventional (immediate release) oral drug products, such as tablets and capsules, are  formulated to release the active drug immediately after oral administration. In the formulation of conventional drug products, no deliberate efforts is made to modify the drug release rate. Immediate-release products generally result in relatively rapid drug absorption and onset of accompanying pharmacodynamic […]

Pharmacokinetics Series – Clearance and Maintenance Dose

14-Mar-15

Clearance and Maintenance Dose Clearance can be thought of as the intrinsic ability of the body or its organs of elimination (usually the kidneys and the liver) to remove drug from the blood or plasma. Clearance is expressed as a volume per unit of time. It is important to emphasise that clearance is not an […]