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Tag Archives: Histamine

Gastric Secretion and Its Regulation


Regulation Mechanism of Gastrirc Secretion Short and Long Reflexes Neural input provides an important mechanism for regulation of gastric secretion. Reflexes contribute to both the stimulation and inhibition (e.g., CGRP) of secretion. For example, distension of the stomach wall, sensed by stretch receptors, activates reflexes that stimulate acid secretion at the level of the parietal […]

Arteriolar Tone and Its Regulation (Local Mechanisms)


I.Arteriolar Tone A.Basal tone B.ANS C.Adrenal Glands D.Local 1.Metabolic substances 2.Endothelial cells secretion 3.Other local chemical influences 4.Transmural pressure (myogenic response) II.Venous Tone A.Basal tone (little) B.ANS C.Adrenal glands D.Internal pressure (recall deltaV/deltaP = C) E.External compression (muscle pump) Because the body's needs are continually changing, the cardiovascular system must continually make adjustments in the diameter […]

Inflammation Mediators


The mediators of inflammation are the substances that initiate and regulate inflammatory reactions. The most important inflammation mediators include vasoactive amines, lipid products (prostaglandins and leukotrienes), cytokines (including chemokines), and products of complement activation. These mediators induce various components of the inflammatory response typically by distinct mechanisms, which is why inhibiting each has been therapeutically beneficial. However, there is also some […]