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Tag Archives: distribution

Pharmacokinetics – Distribution Series

11-Nov-17

As a result of either direct systemic administration or absorption from an extravascular route, drug reaches the systemic circulation, where it very rapidly distributes throughout the entire volume of plasma water and is delivered to tissues around the body. Two aspects of drug distribution need to be considered: how radidly, and to what extent, the […]

Inferences for Population Proportions

24-Sep-17

Confidence Intervals for One Population Proportion Statisticicans often need to determine the proportion (percentage) of a population that has a specific attribute. Some examples are: the percentage of U.S. adults who have health insurance the percentage of cars in the United States that are imports the percentage of U.S. adults who favor stricter clean air […]

[Clinical Art][Pharmacokinetics] Interpretation of Plasma Drug Concentrations (Steady-State)

11-Nov-16

Plasma drug concentration are measured in the clinical setting to determine whether a potentially therapeutic or toxic concentration has been produced by a given dosage regimen. This process is based on the assumption that plasma drug concentrations reflect drug concentrations at the receptor and, therefore, can be correlated with pharmacologic response. This assumption is not […]