Skip to content

Tag Archives: Clearance

[Clinical Art][Pharmacokinetics] Interpretation of Plasma Drug Concentrations (Steady-State)


Plasma drug concentration are measured in the clinical setting to determine whether a potentially therapeutic or toxic concentration has been produced by a given dosage regimen. This process is based on the assumption that plasma drug concentrations reflect drug concentrations at the receptor and, therefore, can be correlated with pharmacologic response. This assumption is not […]

[Endocrinology] The Regulation and Clinical Art of Thyroid Hormones


Thyroid Hormone Synthesis Process The Source Components of Thyroid Hormone Thyroglobulin (Tg), plays an important role in the synthesis and storage of thyroid hormone. Tg is a glycoprotein containing multiple tyrosine residues. It is synthesized in the thyroid follicular epithelial cells and secreted through the apical membrane into the follicular lumen, where it is stored […]

The TDM of Vancomycin


Question #1. B.C., a 65-year old, 45-kg man with a serum creatinine concentration of 2.2 mg/dL, is being treated for a presumed hospital-acquired, MRSA infection. Design a dosing regimen that will produce peak concentration less than 40 to 50 mg/L and through concentrations of 5 to 15 mg/L. Target Plasma Concentration Clearance and Volume of […]

Pharmacokinetics Series – Clearance and Maintenance Dose


Clearance and Maintenance Dose Clearance can be thought of as the intrinsic ability of the body or its organs of elimination (usually the kidneys and the liver) to remove drug from the blood or plasma. Clearance is expressed as a volume per unit of time. It is important to emphasise that clearance is not an […]