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Tag Archives: Cardiac Output

Factors That Alter Clearance


Body Surface Area (BSA) Most literature values for clearance are expressed as volume/kg/time or as volume/70 kg/time. There is some evidence, however, that drug clearance is best adjusted on the basis of BSA rather than weight. The patient’s BSA can be obtained from a nomogram, estimated from below: BSA in m2 = [(Patient’s Weight in […]

ASH Guideline for RBC Transfusion


The Guideline The development of clinical practice guidelines for RBC transfusion has been challenged by a limited availability of high-quanlity evidence to support practice recommendations. There is general agreement that RBC transfusion is typically not indicated for hemoglobin (Hgb) levels of >10 g/dL and that transfusion of RBCs should be considered when Hb is <7 […]

[Physiology] Vascular Control in Specific Organs


In General Basal tone, local metabolic vasodilator factors, and sympathetic vasoconstrictor nerves acting through alpha1-receptors are the major factors controlling arteriolar tone and therefore the blood flow rate through peripheral organs. Sympathetic vasoconstrictor nerves, internal pressure, and external compressional forces are the most important influences on venous diameter and therefore on peripheral-central distribution of blood […]

Vascular Resistances and Compliance, MAP and Pulse Pressure


Resistances In A Single Organ In an organ, the consecutive vascular segments are arranged in series within an organ. Therefore, the overall vascular resistance of the organ must equal the sum of the resistances of its consecutive vascular segments, Because arterioles have a large vascular resistance in comparison to the other vascular segments (see above), […]