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Category Archives: Transplantation

Specific Immunosuppressive Therapy


The ideal immunosuppressant would be antigen-specific, inhibiting the immune response to the alloantigens present in the graft (or vice versa alloantigens present in recipient in GVHD) while preserving the recipient's ability to respond to other foreign antigens. Although this goal has not yet been achieved, several more targeted immunosuppressive agents have been developed. Most involve […]

The Management of Multiple Myeloma in Younger Patients


Therapy for multiple myeloma (MM) has advanced with gratifying speed over the past 5 to 7 years and with this progress, a degree of uncertainty has arisen about optimal approaches to therapy, particularly in the newly diagnosed patients. Indeed, using mordern therapeutic strategies, living with MM for a decade or longer has now become a […]

The Mangement of Relapsed AML


The only cure of an adult with relapsed AML is a transplantation. However, three important questions shoul be solved when managing relapsed AML. Whether the patients with relapsed AML should receive a transplantation in untreated relapse rather than undergo reinduction therapy. Which regimen should be offered to patients with relapsed AML for the purpose of […]

The Management of Acute Lymphoblastic Leukemia in Adults (Stratetgies)


Acute lymphoblastic leukemia (ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. ALL is a heterogeneous disease, both in terms of its pathology and the populations that it affects. Prognostic Factors and Risk Categories Several factors determine the prognosis […]

Anti-infection Prophylaxis in Cancer Patients With Neutropenia (Drug Selection)


Because evidence was unavailable from trials limited to outpatients, the ASCO Panel considered evidence from studies on inpatients or mixed populations, and the recommendatons are based on the summarized evidence and Panel members’ expert opinion. Antibacterial Prophylaxis Majority of randomly assigned patients in studies were hospitalized and treated for hematolgic malignancies. Taken together, evidence shows […]