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Category Archives: Therapeutics

Variability – Differ in Drug Response


Substantial differences in response to drugs commonly exist among patients. Such between or interindividual variability is often reflected by various marketed dose strengths of a drug. Because variability in response within a subject from one occasion to another (intraindividual variability) is generally smaller than interindividual variability, there is usually little need to subsequently adjust an […]

[Clinical Skills] Therapeutics Planning


Also see Pharmacy Profession Forum for the thread "[Diagnosis] Diagnostic Series" at Identify the Problems Step 1 Obtain Patient Data Consider all available patient data. Review all previously charted data (history, physical examination findings, results of laboratory and diagnostic tests) and interview the patient for the patient's medication history. Reviewall relevant data resources, including data […]

Stage, Expression, and Causal Model of Diseases


Natural History of Disease Stage of Disease The natural history of disease refers to the progression of a disease in an individual over time. This includes all relevant phenomena from before initiation of the disease (the stage of susceptibility) until its resolution. In the period following exposure to the causal factor, the individual enters a […]

Polymorphisms in Pharmacotherapy


Polymorphisms related to pharmacotherapy include polymorphisms in genes for drug-metabolizing enzymes, polymorphisms in drug transporter genes, and polymorphisms in drug target genes. Polymorphisms in Genes for Drug-Metabolizing Enzymes Polymorphisms in the drug-metabolizing enzymes represent the first recognized and, so far, the most documented examples of genetic variants with consequences in drug response and toxicity. eTable […]

The Management of Hypertension (Clinical Evaluation)


Frequently, the only sign of essential hypertension is elevated BP. The rest of the physical examination may be completely normal. However, a complete medical evaluation including a comprehensive medical history, physical examination, and laboratory and/or diagnostic test is recommended after diagnosis to identify secondary causes, identify other CV risk factors or comorbid conditions that may […]