Skip to content

Category Archives: Pharmacotherapy

[Clinical Skills] Therapeutics Planning


Also see Pharmacy Profession Forum for the thread "[Diagnosis] Diagnostic Series" at Identify the Problems Step 1 Obtain Patient Data Consider all available patient data. Review all previously charted data (history, physical examination findings, results of laboratory and diagnostic tests) and interview the patient for the patient's medication history. Reviewall relevant data resources, including data […]

Polymorphisms in Pharmacotherapy


Polymorphisms related to pharmacotherapy include polymorphisms in genes for drug-metabolizing enzymes, polymorphisms in drug transporter genes, and polymorphisms in drug target genes. Polymorphisms in Genes for Drug-Metabolizing Enzymes Polymorphisms in the drug-metabolizing enzymes represent the first recognized and, so far, the most documented examples of genetic variants with consequences in drug response and toxicity. eTable […]

The Management of Hypertension (Clinical Evaluation)


Frequently, the only sign of essential hypertension is elevated BP. The rest of the physical examination may be completely normal. However, a complete medical evaluation including a comprehensive medical history, physical examination, and laboratory and/or diagnostic test is recommended after diagnosis to identify secondary causes, identify other CV risk factors or comorbid conditions that may […]

Pharmacokinetics Series – Clearance and Maintenance Dose


Clearance and Maintenance Dose Clearance can be thought of as the intrinsic ability of the body or its organs of elimination (usually the kidneys and the liver) to remove drug from the blood or plasma. Clearance is expressed as a volume per unit of time. It is important to emphasise that clearance is not an […]

Inflammation Mediators


The mediators of inflammation are the substances that initiate and regulate inflammatory reactions. The most important inflammation mediators include vasoactive amines, lipid products (prostaglandins and leukotrienes), cytokines (including chemokines), and products of complement activation. These mediators induce various components of the inflammatory response typically by distinct mechanisms, which is why inhibiting each has been therapeutically beneficial. However, there is also some […]