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Category Archives: Pharmacogenetics

Inherited Variation and Polymorphism in DNA

03-Aug-17

The original Human Genome Project and the subsequent study of now many thousands of individuals worldwide have provided a vast amount of DNA sequence information. With this information in hand, one can begin to characterize the types and frequencies of polymorphic variation found in the human genome and to generate catalogues of human DNA sequence […]

Variability – Differ in Drug Response

13-Apr-17

Substantial differences in response to drugs commonly exist among patients. Such between or interindividual variability is often reflected by various marketed dose strengths of a drug. Because variability in response within a subject from one occasion to another (intraindividual variability) is generally smaller than interindividual variability, there is usually little need to subsequently adjust an […]

How Pharmacogenetics Affects Drug Therapy

29-Mar-16

Polymorphisms of genes can affect drug therpay in three ways: polymorphisms in genes for drug-metabolizing enzymes, polymorphisms in genes encoding for drug transporters, and polymorphisms in genes encoding for drug targets. Polymorphisms in Genes for Drug-Metabolizing Enzymes Polymorphisms in the drug-metabolizing enzymes represent the first recognized and, so far, the most documented examples of genetic variants […]

Polymorphisms in Pharmacotherapy

10-Nov-15

Polymorphisms related to pharmacotherapy include polymorphisms in genes for drug-metabolizing enzymes, polymorphisms in drug transporter genes, and polymorphisms in drug target genes. Polymorphisms in Genes for Drug-Metabolizing Enzymes Polymorphisms in the drug-metabolizing enzymes represent the first recognized and, so far, the most documented examples of genetic variants with consequences in drug response and toxicity. eTable […]

Factors Contributing to Drug-Induced Diseases

28-May-15

Pharmacokinetic and pharmacodynamic factors Toxic or exaggerated responses to normal drug doses can lead to drug-induced diseases and other adverse events for two reasons. First, excessively high concentrations of unbound drug or metabolite at the site of action may occur as a result of unusual pharmacokinetics (absorption, distribution, metabolism, excretion) of the drug or metabolites. […]