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Category Archives: Cytogenetics

Inherited Variation and Polymorphism in DNA

03-Aug-17

The original Human Genome Project and the subsequent study of now many thousands of individuals worldwide have provided a vast amount of DNA sequence information. With this information in hand, one can begin to characterize the types and frequencies of polymorphic variation found in the human genome and to generate catalogues of human DNA sequence […]

[Clinical Art][Physiology] Iron Physiology

03-Nov-16

Global Iron Homeostasis Under normal conditions, dietary iron is usually 15-25 mg daily, of which 5%-10% (1-2 mg) is absorbed through the gastrointestinal (GI) tract and the same amount lost by desquanmation of GI epithelial cells, epidermal cells of the skin, and, in menstruating women, red bood cells. The average total body content of iron […]

The Etiology of Primary Dyslipidemia

12-May-14

Generally primary dyslipidemia are due to mutations of various genes. Thus these disorders of lipid are¬†inheritable and have a obvious family history, which is important in dignosing the primary dyslipidemia. Primary disorders of lipid consist of disorders of elevated apoB-containing lipoproteins, disorders of low apoB-containing lipoproteins level, disorders of low HDL-C level, and disorders of […]

The Management of Multiple Myeloma in Younger Patients

19-Sep-13

Therapy for multiple myeloma (MM) has advanced with gratifying speed over the past 5 to 7 years and with this progress, a degree of uncertainty has arisen about optimal approaches to therapy, particularly in the newly diagnosed patients. Indeed, using mordern therapeutic strategies, living with MM for a decade or longer has now become a […]

The Management of Therapy-related Acute Meyloid Leukemia

01-Jul-13

Until recently, the term “secondary leukemia” broadly included any AML with a history of prior malignancy as well as patients with any antecedent hematologic disorder and, in some series, any patient who presented with unfavorable cytogenetics. Among therapy-related AML patients, 70% present with abnormalities of chromosome 5 or 7, which is the most typical presentation […]