Skip to content

Category Archives: Adverse Drug Reactions

Variability – Differ in Drug Response


Substantial differences in response to drugs commonly exist among patients. Such between or interindividual variability is often reflected by various marketed dose strengths of a drug. Because variability in response within a subject from one occasion to another (intraindividual variability) is generally smaller than interindividual variability, there is usually little need to subsequently adjust an […]

Factors Contributing to Drug-Induced Diseases


Pharmacokinetic and pharmacodynamic factors Toxic or exaggerated responses to normal drug doses can lead to drug-induced diseases and other adverse events for two reasons. First, excessively high concentrations of unbound drug or metabolite at the site of action may occur as a result of unusual pharmacokinetics (absorption, distribution, metabolism, excretion) of the drug or metabolites. […]

How to Choose, Monitor, and Evaluate the Therapeutic Regimen (Pharmacologic Perspective)


The relation between drug dose and clinical response is compared with drug concentration/dose and pharmacologic response. The relation between drug concentration and drug response is in carefully controlled systems in vitro, which can be relative simple. Conversely, the relation between dose of a drug and the clinically observed response may be complex (actually it is true). […]

Make a provider and patient education for levothyroxine


Today I would like to write something about levothyroxine. My hospital uses levothyroxine often. Everyday there are lots of patients prescribed with levothyroxine. I do believe it is necessary to write below for education, which is not only for patients but also providers. The reference I use comes from U.S. FDA’s official drug information database. […]

Complications of The Care of Multiple Myeloma


As a clinical pharmacist you should always know the adverse effect of the pharmacotherapy. That is why we are trained again and again. That is we are educated for. This is more important for oncology pharmacists because the chemotherapy always is relevant to adverse reactions which are commonly grade 3/4. Last post we talked about […]