Skip to content

Monthly Archives: May 2017

The Process of Differential Diagnosis


Elements of the Differential Diagnosis Decision-making on the Basis of Diagnosis. The physician endeavors to organize the subjective complaints and the objective findings of a patient in order to receive further indications to proceed. This approach is frequently chosen because a diagnosis in the conventional sense is not always easy to make, as more than […]

Conceiving the Research Question and Developing the Study Plan


The research question is the uncertainty that the investigator wants to resolve by performing his/her study. There is no shortage of good research questions, and even as we succeed in answering some questions, we remain surrounded by others. Clinical trials, for example, established that treatments that block the synthesis of estradiol (aromatase inhibitors) reduce the […]

Outline of A Study


This is the one-page study plan of a project carried out by Valerie Flaherman, MD, MPH, begun while she was a general pediatrics fellow at UCSF. Most beginning investigators find observational studies easier to pull off, but in this case a randomized clinical trial of modest size and scope was feasible, the only design that […]

Evaluation of Renal Function


Assessment of kidney function using both qualitative and quantitative methods is an important part of the evaluation of patients and an essential characterization of individuals who participate in clinical research investigations. Estimating of creatinine clearance has been considered the clinical standard for assessment of kidney function for nearly 50 years, and continues to be used […]