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Monthly Archives: April 2017

Clinical Skills – Cluster the Clinical Findings


It is often challenging to decide whether clinical data fit into one problem or several problems. If there is relatively long list of symptoms and signs, and an equally long list of potential explanations, one approach is to tease out separate clusters of observations and analyze one cluster at a time. Several clinical characteristics may […]

The Comprehensive Adult Health History


Initial Information Data and Time of History The date is always important. Be sure to document the time you evaluate the patient, especially in urgent, emergent, or hospital setitngs. Identify Data These include age, gender, marital status, and occupation. The source of history or referral can be the patient, a family member or friend, an […]

Variability – Differ in Drug Response


Substantial differences in response to drugs commonly exist among patients. Such between or interindividual variability is often reflected by various marketed dose strengths of a drug. Because variability in response within a subject from one occasion to another (intraindividual variability) is generally smaller than interindividual variability, there is usually little need to subsequently adjust an […]

Mass Balance


The mass balance technique has been suggested as a more direct alternative to the iterative approach. The mass balance technique is relatively simple and can be best visualized by examining the relationship between the rate of drug administration and the rate of drug elimination. At steady state, the rate of drug elimination (RE) is equal […]