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Monthly Archives: July 2016

Renal Potassium Reabsorption and Secretion

24-Jul-16

Percentage of fitered load transported at different locations depending on diet The Importance of Potassium Balance The vast majority of body potassium is freely dissolved in the cytosol of tissue cells and constitutes the major osmotic component of the intracellular fluid (ICF). Only about 2% of total-body potassium is in the extracellular fluid (ECF). This small […]

Regulation of Water Excretion

23-Jul-16

Water excretion, as with sodium excretion, is regulated in partnership with the CV system. Central goals in regulating both salt and water excretion are to: 1).preserve vascular volume and 2).maintain plasma osmolality at a level that is healthy for tissue cells. The main regulators of water excretion, not surprisingly, relate to osmolality and volume. Quantitatively, […]

Specific Immunosuppressive Therapy

20-Jul-16

The ideal immunosuppressant would be antigen-specific, inhibiting the immune response to the alloantigens present in the graft (or vice versa alloantigens present in recipient in GVHD) while preserving the recipient's ability to respond to other foreign antigens. Although this goal has not yet been achieved, several more targeted immunosuppressive agents have been developed. Most involve […]

[Physiology][Hematology] Coagulation Factors, Anticoagulation Factors, and Pathways of Hemostasis and Thrombosis

14-Jul-16

The role of surfaces in coagulation and coagulation inhibition and fibrinolysis Functionally, the relationship between clotting and surface is striking. For a process that is typically termed humoral, most of the coagulation reactions take place on biologic surfaces. The presence of a phospholipid surface increases the rate of activation of prothrombin by several orders of magnitude. […]

ASH Guideline for RBC Transfusion

13-Jul-16

The Guideline The development of clinical practice guidelines for RBC transfusion has been challenged by a limited availability of high-quanlity evidence to support practice recommendations. There is general agreement that RBC transfusion is typically not indicated for hemoglobin (Hgb) levels of >10 g/dL and that transfusion of RBCs should be considered when Hb is <7 […]