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Monthly Archives: June 2014

The Properties of Drugs – Receptor Rationale


The definition of drug, in the most general sense, is that a drug may be defined as any substance that brings about a change in biologic function through its chemical actions. The Foundational Section Generally, four primary factors affect drug-receptor interactions, including 1.drug’s affinity to the according receptor (with respect to Kd);2.the efficiency of the […]

Mechanism of Thermoregulation


The normal body core temperature is 36.6℃ to 38.3℃ (via rectal), 36 to 37.7℃ (via oral), respectively. The temperature is fluctuating, with lowest in the early morning and highest in the late afternoon or early evening. Even in patients with fever, this diurnal variation of body temperature still exists. The thermoregulation is based on heat production […]

The Autoregulation of Renal Blood Flow


Part I The capacity of tissues to regulate their own blood flow is referred to as autoregulation. Most vascular beds have an intrinsic capacity to compensate for moderate changes in perfusion pressure by changes in vascular resistance, so that blood flow remains relative constant. This capacity is well developed in the kidneys (see Part II), […]

Pathophysiology of Selected Vascular Disorders


Atherosclerosis A condition that afflicts the large and medium-sized arteries of almost every human, at least in societies in which cholesterol-rich foodstuffs are abundant and cheap, is atherosclerosis. This condition begins in childhood and, in the absence of acelerating factors, develops slowly until it is widespread in old age. However, it is accelerated by a […]