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Monthly Archives: February 2013

Diagnosis of Myelofibrosis


Current diagnosis of PMF is based on the 2008 World Health Organization (WHO) criteria, which enlist histopathologic, morphologic, clinical, and molecular-cytogenetic variables. The diagnosis of post-PV or post-ET MF is according to IWG-MRT criteria. Table 1 Diagnostic Criteria of Myelofibrosis In all 3 MF variants, typical laboratory features include anemia, peripheral blood leukoerythroblastosis, dacryocytosis, leukocytosis/thrombocytosis, […]

Drug Targets and Cell Signaling Pathways


There are cell signaling pathways and they are Erb pathway, VEGF pathway, PARP pathway, IGF-1 pathway, Hedgehog (Hh) pathway, and Ubiquitin-Proteosome pathway. Erb pathway There are four types of Erb receptors including EGFr (ErbB1), HER2/neu (ErbB2), HER3 (ErbB3), and HER4 (ErbB4). Ligands of these receptors bind to Erb receptors, then dimerization happens, finally the tyrosine kinase of receptors are […]

Conditioning Regimen for Hematopoietic Stem Cell Transplation (HSCT)


There are two categories of HSCT, autologous HSCT (ASCT) and allogeneic HSCT (allo-SCT). For patients being considered for ASCT, the most common reason for choosing a particular conditioning regimen is the disease for which transplantation is being considered. For patients being considered for allo-SCT, the initial choice of a conditioning regimen is based on the […]

UCSF/SFGH/VASF Guidelines for Antimicrobial Use in Adults


Below is the guideline for adults antimicrobial use, including the renal impairment dosage adjustment. UCSF School of Pharmacy provides the information of this guideline and I translated portion of the table into Chinese. I hope this information will help anyone who need it. Table 1 UCSF/SFGH/VASF Guidelines for Antimicrobial Use in Adults 成人抗微生物药物剂量调整 药物 CrCl>50ml/min CrCl […]

Make a provider and patient education for levothyroxine


Today I would like to write something about levothyroxine. My hospital uses levothyroxine often. Everyday there are lots of patients prescribed with levothyroxine. I do believe it is necessary to write below for education, which is not only for patients but also providers. The reference I use comes from U.S. FDA’s official drug information database. […]